New trends in the neurobiology and pharmacology of affective disorders.
نویسندگان
چکیده
Although depression is a common disorder that is often resistant to pharmacotherapy, its pathophysiology has remained elusive. Since the early 1950s, when the first antidepressants were introduced, i.e., the non-selective MAO inhibitors and tricyclic drugs, a number of hypotheses describing ethiopathogenesis of depression and antidepressant drug action have been formulated. The Institute of Pharmacology, the Polish Academy of Sciences has performed experimental and clinical research focused on the pathophysiology of depression and the mechanisms of action of antidepressant drugs for over 40 years. Our results from this period have significantly contributed to understanding the complex mechanisms of antidepressant drug actions and new pathways that underpin the pathophysiology of depression. Most of these theories are based on the finding that the chronic administration of antidepressants leads to adaptive changes in pre- and post-synaptic monoaminergic and glutamatergic neurotransmission as well as to alterations in gene transcription and immune-inflammatory and neurotrophic factors, resulting in neuroplastic changes in the brain. Taking into account the functional interdependence of the neuronal, hormonal and immunologic systems, we propose neurodevelopmental and neuroimmune theories for affective disorders. Moreover, commonalities have been documented for the pathomechanisms of depression and neurodegenerative and metabolic disorders as well as drug dependence. The aim of this special issue is to briefly present the major research contributions and the new research directions of the Institute of Pharmacology, the Polish Academy of Sciences with respect to the neurobiology of affective disorders and the mechanisms of action of marketed and new putative antidepressant drugs.
منابع مشابه
New Hopes and Challenges for Treatment of Neurodegenerative Disorders: Great Opportunities for Young Neuroscientists
متن کامل
The relationship between friendship quality, affective style and obsessive-compulsive, avoidant and dependent personality disorder symptoms
Abstract Interpersonal relationships and emotions are two factors which affected mental health, and can play an important role in the formatting or continuing of maladaptive personality traits. The aim of this study was to investigate the relationship between friendship quality and affective style with obsessive-compulsive, avoidant and dependent personality disorder. For this purpose, 400 f...
متن کاملBrain complexity increases during the manic episode of bipolar mood disorder type I
Fractal dimension of the electroencephalographic (EEG) signal has been argued to reflect the complexity of the underlying brain processes. To this date, conventional studies of EEG in mood disorders have not been able to distinguish between patients and normal individuals. Here we show that, compared to normal subjects, EEG fractal dimension is significantly augmented in the manic episode of bi...
متن کاملBrain complexity increases during the manic episode of bipolar mood disorder type I
Fractal dimension of the electroencephalographic (EEG) signal has been argued to reflect the complexity of the underlying brain processes. To this date, conventional studies of EEG in mood disorders have not been able to distinguish between patients and normal individuals. Here we show that, compared to normal subjects, EEG fractal dimension is significantly augmented in the manic episode of bi...
متن کاملThe Comparison of affective-emotional temperament in women with and without sexual Interest/Arousal Disorder
affective-emotional temperament in women with and without sexual Interest/Arousal Disorder. The research was a descriptive causal-comparative study. For this purpose, 65 women with sexual desire /arousal disorders and 85 women without disorders were selected purposefully among all women who attended a stadium in Rasht city in 2018-19. To collect data, women’s sexual interest and desire question...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Pharmacological reports : PR
دوره 65 6 شماره
صفحات -
تاریخ انتشار 2013